Viruses and Type 1 Diabetes: From Enteroviruses to the Virome
نویسندگان
چکیده
For over a century, viruses have left long trail of evidence implicating them as frequent suspects in the development type 1 diabetes. Through vigorous interrogation viral infections individuals with islet autoimmunity and diabetes using serological molecular virus detection methods, well mechanistic studies virus-infected human pancreatic ?-cells, prime been narrowed down to predominantly enteroviruses. Here, we provide comprehensive overview supporting hypothesised role enteroviruses We also discuss concerns historical focus investigation bias toward summarise current unbiased efforts aimed at characterising complete population (the “virome”) contributing early life Finally, review range vaccine antiviral drug candidates currently being evaluated clinical trials for prevention potential treatment
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ژورنال
عنوان ژورنال: Microorganisms
سال: 2021
ISSN: ['2076-2607']
DOI: https://doi.org/10.3390/microorganisms9071519